Neuromedin B is a new player in cartilage formation
نویسندگان
چکیده
منابع مشابه
Neuromedin B is present in lung cancer cell lines.
Previously, high levels of gastrin-releasing peptide and its mRNA were detected in classic small cell lung cancer cell lines. Here the ability of lung cancer cell lines to synthesize neuromedin B (NMB), a structurally similar mammalian bombesin-like peptide, was investigated. By radioimmunoassay, NMB (0.1-0.7 pmol/mg of protein) was detected in 23 of 33 lung cancer cell lines. In contrast, gast...
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Here we used an array-based differential screen to uncover the expression of the neuropeptide neuromedin B (NMB) in the trigeminal ganglia of mice. Double-labeling experiments reveal NMB is expressed in a subset of sensory neurons that colabel with calcitonin gene-related peptide and TRPV1 suggestive of a role for NMB in nociception. Indeed, administration of NMB antagonist greatly attenuates e...
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A novel 36-amino acid neuropeptide, neuromedin S (NMS), has recently been identified in rat brain and has been shown to be an endogenous ligand for two orphan G protein-coupled receptors, FM-3/GPR66 and FM-4/TGR-1. These receptors have been identified as neuromedin U (NMU) receptor type 1 and type 2, respectively. In this study, the physiological role of the novel peptide, NMS, on feeding regul...
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cytoskeletal reorganization, morphogenesis, and cell migration (Figure 1). β 1 Pix also exhibits non-canonical activities in which it serves as a scaffolding protein in some signaling pathways (Pavlov et al., 2010). Staruschenko and Sorokin (2012) also provide an overview of the expression of βPix in the kidney and the various roles of βPix in kidney function. Recently, βPix expression has been...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2020
ISSN: 1063-4584
DOI: 10.1016/j.joca.2020.02.151